中药益气通络方治疗气阴两虚型糖尿病视网膜病变的临床观察 活血益气通络的中成药

　　【摘要】目的观察自拟中药益气通络方治疗气阴两虚型糖尿病视网膜病变的临床的疗效。方法将62例中医辨证为气阴两虚型的2型糖尿病视网膜病变患者随机分为两组，每组31例，对照组给予降脂药、降压药及生物合成人胰岛素进行综合治疗，观察组仅给予自拟中药益气通络方治疗，两组均以2周为1疗程，连续治疗3个疗程后，对两组临床疗效进行评价，并测定两组治疗前后相关生化指标的变化以评定其安全性。结果经3个疗程的治疗后，观察组总有效率为933%，对照组总有效率为767%，两组比较差异有统计学意义(P005)，而观察组以上指标较治疗前无明显变化。结论自拟中药益气通络方治疗糖尿病视网膜病变与西药综合治疗疗效相当，具有较好疗效，且对肝肾功能无明显损伤，较单纯西药治疗更安全可靠。
　　【关键词】糖尿病视网膜病变；气阴两虚型；益气通络方
　　Clinical observation of traditional Chinese medicine prescription benefiting vital energy and dredging collaterals on diabetic retinopathy with Qiyin DeficiencyYAO Jinlin Dali County Chinese Medicine Hospital, Dali 715100,China
　　【Abstract】ObjectiveTo observe clinical efficacy of traditional Chinese medicine prescription benefiting vital energy and dredging collaterals on diabetic retinopathy with Qi yin Deficiency Methods62 patients with diabetic retinopathy were divided into observation group and control group randomly，with 31 cases in each group, patients of the control group were given combined modality therapy by reducing blood cholesterol and blood pressure and injecting biosynthetic human insulin,while patients of the observation group were given traditional Chinese medicine prescription benefiting vital energy and dredging collaterals only After six weeks treatment,the clinical effects and safety were estimated in both group ResultsAfter three courses treatment, the effective rate of observation group(839%) is generally the same as that of control group(871%) (P>005); but biochemical indicators such as aspartate aminotransferase(AST), glutamicoxal(o)acetic transaminase(ALT), blood urea nitrogen(BUN)and glutathione reductase(Gr) of the control group decreased significantly compared to pretreatment while those indicators of the observation group remained almost the same with pretreatment, and they are all in range of normal valueConclusionTraditional Chinese medicine prescription benefiting vital energy and dredging collaterals is effective and safe on patients of diabetic retinopathy with Qiyin Deficiency, which is of the same power with the combined modality therapy，but has less side effects than control group.
　　【Key words】Diabetic retinopathy; Qiyin Deficiency; Traditional chinese medicine prescription benefiting vital energy and dredging collaterals
　　作者单位：715100陕西省大荔县中医医院糖尿病视网膜病变(diabetic retinopathy，DR)是糖尿病最常见也是最严重的微血管并发症，30%～50%的糖尿病患者会并发DR，该病也是世界四大致盲疾病之一［1］。单纯期DR以眼底静脉扩张、微血管瘤和出血等症状为主，当病变累及黄斑，引起玻璃体积血、新生血管破裂等广泛的增殖性病变出现时，则会对视力产生明显损害，严重者最后会因视网膜脱落和出血性青光眼导致失明［2］。目前西药对于DR尚无特效治疗方法，我院自2010年2月至2012年1月以中药益气通络方剂治疗气阴两虚型糖尿病视网膜病变患者31例，与采用西药综合治疗的对照组相比，疗效相当，且副作用较小，疗效满意，现将结果报告如下。